Welcome to the Natesh Structural Molecular Biology laboratory (NSMB) Lab. The NSMB Lab is located in the School of Biology, Indian Institute of Science Education and Research Thiruvananthapuram.
The 2017 Noble prize in Chemistry goes to CryoEM. Click the link here for more details.
Research Interests in NSMB Lab :
Crystallography and CryoEM structural studies of complexes of signal transduction proteins in Cardiovascular Disease, proteins involved in Mycobacterium Tuberculosis and DNA damage repair.
Life shows its spectacular colours in its myriad diversity, yet life shares certain fundamental common elements like proteins, DNA etc. Students and researchers can build upon knowledge gained from observations in simple models to study even more complex problems. Our lab aims to study the individual and complex multi-protein (protein-protein, protein-non native protein etc.) , protein-ligand (protein-inhibitor, protein-DNA etc.) interactions by tackling the individual problems and assembling them to get a broader view. Towards this we use two principle techniques viz., Protein Crystallography(PX) and Cryo Electron microscopy(CryoEM) along with bioinformatics and range of other biophysical (DLS, MALS, CD, Fluorescence), biochemical and molecular biology techniques.