Welcome to the Natesh Structural  Molecular Biology laboratory (NSMB) Lab.    The NSMB Lab is located in the School of BiologyIndian Institute of Science Education and Research Thiruvananthapuram.

We are conducting an EMBO Practical course on cryoEM at IIT-Delhi in Mar 2018.

18–29 March 2018 | IN–New Delhi
EMBO Practical Course
CEM3DIP 2018: of macromolecular assemblies and cellular tomography
Contact: Ramanathan Natesh
Subject area(s): Structural Biology & Biophysics

Last date for online application is over now.  Go to course webpage for  more details.  For more details, please contact cem3dip2018@iisertvm.ac.in

The 2017 Noble prize in Chemistry  goes to CryoEM.  Click the link here for more details.

Research Goals:

Research Interests  in NSMB Lab :

Crystallography and CryoEM structural studies of complexes of signal transduction proteins in Cardiovascular Disease, proteins involved in Mycobacterium Tuberculosis and DNA damage repair.

Life shows its spectacular colours in its myriad diversity, yet life shares certain fundamental common elements like proteins, DNA etc.   Students and researchers can build upon knowledge gained from observations in simple models to study even more complex problems.  Our lab aims to study the individual and complex multi-protein (protein-protein, protein-non native protein etc.) , protein-ligand (protein-inhibitor, protein-DNA etc.) interactions by tackling the individual problems and assembling them to get a broader view.  Towards this we use two principle techniques viz., Protein Crystallography(PX) and Cryo Electron microscopy(CryoEM) along with range of other biophysical (DLS, MALS, CD, Fluorescence), biochemical and molecular biology techniques.