Research & Publications

Research

Research in our laboratory focuses on molecular level understanding of life processes.   In particular we work on Structural Molecular Biology to understand the fascinating microscopic world within us.   We use Molecular Biology, Biochemistry, Structural Biology and Bioinformatics approaches to understand the biology and chemistry within us.   We use mainly protein Crystallography and Single Particle CryoEM  along with other biophysical techniques like CD, DLS, SEC-MALS, SPR, ITC, Fluorescence Spectroscopy, SPR etc. in our lab to understand  Structural Biology aspects macromolecules and macromolecular complexes of life.  The School of Biology has an excellent facility to carry out research using Structural Biology and kindred fields.

Publications

25) Purushothaman M, Dhar SK,Natesh R*Role of unique loops in oligomerization and ATPase function of Plasmodium falciparum gyrase B. Protein Sci. 2021 Oct 29. doi: 10.1002/pro.4217. Online ahead of print.

24) Luwang JW, Nair AR, Natesh R*. (2021).Stability of p53 oligomers: Tetramerization of p53 impinges on its stability. Biochimie.  doi: 10.1016/j.biochi.2021.06.012.

23) Maddi ER, Raghavan SC, Natesh R*. (2021). Hypomorphic mutations in human DNA ligase IV lead to compromised DNA binding efficiency, hydrophobicity and thermal stability.  Protein Eng Des Sel. 2021 Feb 15;34:gzab001. doi: 10.1093/protein/gzab001.

22) Maddi ER, Natesh R*. (2021). Optimization strategies for expression and purification of soluble N-terminal domain of human centriolar protein SAS-6 in Escherichia coli.. Protein Expr Purif.  doi: 10.1016/j.pep.2021.105856.

 

 

 

 

 

 

 

14) Watermeyer JM, Sewell BT, Schwager SL, Natesh R, Corradi HR, Acharya KR, Sturrock ED. (2006). Structure of testis ACE glycosylation mutants and evidence for conserved domain movement. Biochemistry, 45, 12654-12663.

 

 

 

 

 

 

 

 

6) Gordon K, Redelinghuys P, Schwager SL, Ehlers MR, Papageorgiou AC, Natesh R, Acharya KR, Sturrock ED. (2003). Deglycosylation, processing and crystallization of human testis angiotensin-converting enzyme. Biochem. J., 371, 437-442.