Genome Stability Laboratory

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Publications

 

 

1. Rodrigues-Prause, A., Sampaio, N.M.V., Gurol, T.M., Aguirre, G.M., Sedam, H.N.C., Chapman, M.J., Malc, E.P., Ajith, V.P., Chakraborty, P., Tizei, P.A., Pereira, G.A.G., Mieczkowski, P.A., Nishant, K.T. and Argueso JL (2018) A case study of genomic instability in an industrial strain of saccharomyces cerevisiae. G3 (Bethesda) 8: 3703-3713.

2. Nishant K.T and Sanyal K. (2015) The Good, the bad, and the ugly: How to protect chromosome stability from potential threats. BioEssays 37: 717-720.

 

3. Krishnaprasad, G.N., Anand, M.T., Lin, G., Tekkedil, M.M., Steinmetz, L.M. and Nishant, K.T. (2015) Variation in crossover frequencies perturb crossover assurance without affecting meiotic chromosome segregation in Saccharomyces cerevisiae. Genetics 199: 399-412.

 

4. Rakshambikai, R., Srinivasan, N. and Nishant, K.T. (2013) Structural insights into Saccharomyces cerevisiae Msh4-Msh5 complex function using homology modeling. PLoS One 8: e78753.

 

5. Brown, M.S., Lim, E., Chen, C., Nishant, K.T. and Alani, E. (2013) Genetic Analysis of mlh3 Mutations Reveals Interactions Between Crossover Promoting Factors During Meiosis in Baker's Yeast. G3 (Bethesda) 3: 9-22.

 

6. Ma, X*., Rogacheva, M.V*., Nishant, K.T., Zanders, S., Bustamante, C.D., and Alani, E. (2012) Mutation hotspots in yeast caused by long-range clustering of homopolymeric sequences. Cell Reports 1: 36-42.

 

7. Nishant, K.T*., Wei, W*., Mancera, E*., Argueso, L., Schlattl, A., Delhomme, N., Ma, X., Bustamante, C., Korbel, J., Gu, Z., Steinmetz, M. and Alani, E. (2010) The baker’s yeast diploid genome is remarkably stable in vegetative growth and meiosis. PLoS Genetics 6:e1001109. (Featured in faculty of 1000)

 

8. Nishant, K.T., Chen, C., Shinohara, M., Shinohara, A. and Alani, E. (2010) Genetic analysis of MSH4-MSH5 shows that baker’s yeast forms excess crossovers that are not required for viability in meiosis. PLoS Genetics 6: e1001083

 

9. Nishant, K.T., Singh, N. and Alani, E. (2009) Genomic mutation rates: What highthroughput methods can tell us. Bioessays 31: 912-920.

 

10. Nishant, K.T., Plys, A. and Alani, E. (2008) A mutation in the putative MLH3 endonuclease domain confers a defect in both mismatch repair and meiosis in Saccharomyces cerevisiae. Genetics 179: 747-755 (featured in Issue highlights)

 

11. Nishant, K.T., Kumar, C. and Rao, M.R.S (2006) HumHot: A database of human meiotic recombination hot spots. Nuc.Acids.Res. 34: D25-D28.

 

12. Nishant, K.T. and Rao, M.R.S. (2006) Molecular features of meiotic recombination hot spots. BioEssays 28: 45-56.

 

13. Nishant, K.T., Ravishankar, H. and Rao, M.R.S. (2004) Characterization of a mouse recombination hotspot encoding a novel non-protein coding RNA. Mol.Cell.Biol. 24: 5620 – 5634.

 

* (Equal contributors)

 

Book Chapter

 

Agrawal, S., Nishant, K.T. and Rao, M.R.S (2010) Analysis of Meiotic Recombination Hotspots: A Bioinformatics Approach, In Gabriel Fung’s A Practical Guide to Bioinformatics Analysis (pp. 133-149) Queensland, Australia: iConcept Press.