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Error-free chromosome segregation is crucial for the maintenance of genome integrity
in almost all eukaryotic organisms. Chromosome segregation is orchestrated by two
major structural elements in cells: kinetochore (KT) and centrosome. Kinetochore
(KT) builds connections of the chromosomes with the spindle microtubules (MTs)
and establishes proper spindle attachment with the chromosome; on the other hand,
centrosome provides the spindle poles to build the bi-polar spindles. Regulations of
both these processes are crucial for maintaining the fidelity of chromosome
segregation. We study fundamentals of kinetochore and centrosome biology, their
assembly, biogenesis, and cellular processes associated with their functions. Our
research has been aimed to unravel the cellular regulatory pathways that control
kinetochore assembly, spindle-chromosome attachment and centrosome number in
normal and pathological conditions such as human tumor.