Error-free chromosome segregation is crucial for the maintenance of genetic stability
in almost all eukaryotic organisms. Chromosome segregation is orchestrated by two
major structural elements in cells: kinetochore (KT) and centrosome. Kinetochore, a supramolecular protein complex assembled on the centromeric chromatin, establishes connections of the chromosomes with the spindle microtubules (MTs) and thereby ensures chromosome movement and segregation to happen at correct time and space with minimal errors; on the other hand, the centrosome gives rise to the spindle poles to build the bipolar spindle microtubules. Microtubule-kinetochore/chromosome attachment errors are one of the key causal factors for chromosomal abnormalities such as chromosomal rearrangements, deletions, insertions etc. that are prevalent in cancers and various genetic disorders. Aberrant centrosome amplification also contributes to these defects, specifically in solid tumors. We have been aiming to identify the cellular factors, whose malfunctions promote chromosomal errors with an aim to develop potential therapeutic targets against various human diseases.